Studies in mice suggest that two drugs capable of inhibiting the enzyme TrxR-1 – already available commercially for other purposes – reduce inflammation and mortality in patients with sepsis.
An article in Blood shows that administering the anti-hypertensive drug amlodipine in conjunction with conventional chelation therapy helps combat health problems caused by the buildup of iron in organs.
Researchers in the Brazilian states of São Paulo, Amazonas and Pará have demonstrated that extracts from this native plant are rich in gallic acid, which inhibits the action of enzymes that degrade collagen.
A complete database of Tribe Bignonieae, which consists mainly of lianas, contains information on genetics, taxonomy, morphology, geography and evolution.
Projects selected through this joint call for proposals will develop novel routes for the production of biofuels from non-conventional feedstocks, as well as high-value chemicals.
In 1990-2000 the Polar Front shifted southward twice as much as in the previous 900 years, potentially altering ocean temperatures and ecosystem functions.
In studies with tumor stem cells, researchers at Uruguay's University of the Republic have identified regulators with the potential to interfere in the development of cancer cells.
Researchers evaluated the application of a computer model for hydrological disaster prediction and early warning in the Doce river basin, which contains more than 200 Brazilian municipalities.
System that could result in the creation of biosensors for rapid early diagnosis of breast and prostate cancer, among other diseases, was presented at FAPESP Week Montevideo.
To achieve this integration it will be necessary to surmount barriers to power generation from natural resources, a researcher stressed in a presentation to FAPESP Week Montevideo.
Number of foreign professionals with at least one university degree who add value to the economy via knowledge and creativity has grown by over 40% in the last ten years, survey shows.
A multicenter study involving 40 research groups in several countries evaluated more than 7 million genetic variants in samples from almost 13,000 people – the findings are published in Nature Genetics.
This book contains information on how to treat injuries caused by marine and freshwater species and is based on 30 years of medical and zoological research experience.
According to the authors of a paper published in Scientific Reports, these stem cells can be used for treatment, new drug development and disease research.
An international team of researchers that includes Brazilians has imaged the giant binary star system in the greatest detail ever, observing unexpected new structures.
Researchers have produced a tool for reference labs to assist epidemiological surveillance by analyzing clinical samples from patients with suspected infection by dengue, Zika, chikungunya and many other viral agents.
Rock fragments produced unintentionally today by primates in Serra da Capivara National Park in Brazil resemble tools made deliberately 2.6 million years ago by ancestors of humans, study finds.
The unregulated practice of taking colonies from one place to another has made managed stingless bee populations in the Americas more genetically homogeneous.
Experiments described in Nature Neuroscience show that neuronal development is modulated by mechanical signals linked to nerve tissue stiffness or softness, as well as chemical signals.
Scientists at the Research Center for Gas Innovation are planning a roadmap to assess the technological, economic and environmental factors that could influence the use of NG as marine fuel.
GOAmazon researchers describe in Nature the role of clouds as transporters of particles between the ground and the upper atmosphere. New knowledge will enhance climate models.
Researchers who developed a toadfish venom antiserum have discovered that the venom contains a peptide that has anti-inflammatory activity and may be used to treat multiple sclerosis.
Experiments with animals show that reducing dietary caloric intake by 40% protects neurons from damage caused by excessive calcium, associated with neurodegenerative disorders such as Alzheimer's disease.
Study shows that investment in research, expansion of mechanization and focus on production of commodities were some of the factors that contributed to this leap.
Experiments with rats show that sleeping less than necessary during pregnancy may impair renal development in offspring and predispose them to disease.
Findings were published in Clinical Infectious Diseases. Another article, published in American Journal of Transplantation, reports manifestations of Zika in transplant recipients.
Brazilian and US researchers present results of trials showing that three different candidate Zika vaccines protected rhesus monkeys against the disease.
Compound controls rise in blood pressure in cases associated with sympathetic hyperactivity. Results of preclinical trials are published in Nature Medicine.