Developed at the University of São Paulo, the model uses protein expression to create a stemness index that analyzes the similarity of tumors to pluripotent stem cells. The article was published in Cell Genomics.
Based on the analysis of the genotypes of 500 volunteers, the research project aims to develop a panel of prognostic biomarkers and differentiate Alzheimer’s disease from other types of dementia using blood tests.
In tests with rodents, researchers from the State University of Campinas and their collaborators found that hyperactivation of the PARP1 protein after exhaustive training was associated with decreased performance, fatigue, and behavioral symptoms of overtraining. Animals treated with a drug that inhibits the molecule’s activity did not exhibit the condition.
The solution is produced using chalcone, a chemical substance from the flavonoid family, and has the potential to be used in agriculture and forest restoration.
Eurídice Monteiro, the former Secretary of Higher Education in Cape Verde, delivered the 5th FAPESP 2025 Conference. She argued that science is a tool for liberation, grounded in African contributions, cognitive justice, and South-South integration.
Researchers at the University of São Paulo extracted genetic material from animals kept in museums for a hundred years and from others living in the wild and concluded that they are a new genus with at least a dozen species. The group is working quickly to identify them all and direct conservation efforts in the Atlantic Forest, where they live.
Researchers at the University of São Paulo and Sapienza Università di Roma obtained the material without the need for high temperatures. The product has many potential applications, ranging from electronics to cosmetics.
Organoids were developed from the blood cells of centenarians who are part of a project conducted at the Human Genome and Stem Cell Research Center to discover genes that protect the brain from the effects of aging.
Cross-referencing climate data and fossils from around 15 million years ago shows that the decline in prey availability may have played a role in the extinction of these felines. Another study cites competition with elephants and an increase in predators as factors that reduced the once diverse antilocaprids to a single species today.
In pre-clinical tests conducted at the University of São Paulo, compounds called batzelladins were effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
According to a study conducted by researchers in the state of São Paulo, Brazil, more deforested areas have fewer species that are more similar to each other and perform the same ecological functions. The authors say this phenomenon compromises the resilience of the ecosystem.
The system, developed by a FAPESP-supported startup, performs an assessment in eight minutes, drastically reducing the time needed to save lives.
The system, developed by a FAPESP-supported startup, performs an assessment in eight minutes, drastically reducing the time needed to save lives.