Developed at the University of São Paulo, the model uses protein expression to create a stemness index that analyzes the similarity of tumors to pluripotent stem cells. The article was published in Cell Genomics.
Based on the analysis of the genotypes of 500 volunteers, the research project aims to develop a panel of prognostic biomarkers and differentiate Alzheimer’s disease from other types of dementia using blood tests.
In tests with rodents, researchers from the State University of Campinas and their collaborators found that hyperactivation of the PARP1 protein after exhaustive training was associated with decreased performance, fatigue, and behavioral symptoms of overtraining. Animals treated with a drug that inhibits the molecule’s activity did not exhibit the condition.
Cross-referencing climate data and fossils from around 15 million years ago shows that the decline in prey availability may have played a role in the extinction of these felines. Another study cites competition with elephants and an increase in predators as factors that reduced the once diverse antilocaprids to a single species today.
Called BR4, the microorganism breaks down PET and produces PHB, a high-quality biopolymer that can be used to manufacture sustainable packaging and for biomedical applications.
In pre-clinical tests conducted at the University of São Paulo, compounds called batzelladins were effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
According to a study conducted by researchers in the state of São Paulo, Brazil, more deforested areas have fewer species that are more similar to each other and perform the same ecological functions. The authors say this phenomenon compromises the resilience of the ecosystem.
The study compared theoretical predictions with data from particle collisions carried out at the LHC and RHIC. Maldacena’s conjecture showed strong convergence with the experimental results.
In a review article, researchers highlight the challenges that must be overcome to increase the performance and lifetime of MS-SOFC fuel cells while reducing the cost and environmental impact.
A study by Brazilian scientists shows that a by-product of industrial sunflower oil extraction can be used to produce functional breads with high nutritional value.
Researchers at a FAPESP-supported research center have combined innovative techniques to determine the chromosome number of species of the genus Vellozia, typical of this montane savannah ecoregion. The result provides support for conservation programs and biotechnological applications.
The system, developed by a FAPESP-supported startup, performs an assessment in eight minutes, drastically reducing the time needed to save lives.
The system, developed by a FAPESP-supported startup, performs an assessment in eight minutes, drastically reducing the time needed to save lives.