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Brazilian researchers studied the case of identical twins in which only one sibling was reinfected and developed complications after a second exposure to the virus. Their analysis showed that the adaptive immune response can be different even between individuals with the same genome.

The study showed that interdisciplinary action facilitates weight loss, improves quality of life and eating behavior, and reduces symptoms of depression.

A call for proposals issued jointly with the Ministry of Science, Technology and Innovation and the Brazilian Internet Steering Committee selected the new research centers, which will focus on health, agriculture, manufacturing, and smart cities.

Trials performed by researchers at the University of São Paulo with healthy young adults show that the right level of protein intake is the key to muscle health, regardless of protein source.

Strategies to increase funding for action-oriented research that helps make societies and economies more resilient, equitable and sustainable were the focus for the Second Global Forum of Funders, held online on April 26-28.

Workers with blood lead levels below the legal ceiling in Brazil expressed a microRNA associated with a decrease in DNA methylation, a physiological process required for the organism to be in balance. However, known clinical manifestations occur when levels are high.

This is the main finding of a study published in Clinical Infectious Diseases. The authors analyzed blood samples collected in a town in the Brazilian Amazon before and after the first wave of the pandemic to detect the presence of antibodies against dengue virus and SARS-CoV-2.

A study by scientists at a FAPESP-supported research center analyzed genetic material from 86 couples in which only one spouse was infected. The results suggest that more frequent variants in the resistant spouses could lead to more efficient activation of natural killer (NK) cells, which are part of the innate immune system, the first barrier against infection.

The research group created a virus capable of acting on specific adult brain regions, helping to elucidate the role of key neurons in the prefrontal cortex. They tested the technique on mice.

Conclusion was drawn from a study that involved 92 adolescents aged 11-18. The findings underscore the importance of considering differences between the sexes when treatment is planned.

Whole mitochondrial DNA sequencing of the three extant species of the aquatic mammal shows that they first split from their common ancestor after geological events isolated the South American region from the sea. The African species may have originated in migration borne by marine currents.

A review article by Brazilian researchers shows that alterations in the defense cell metabolism may explain why many patients who survive sepsis die within a year or suffer from long-term complications

Brazilian scientists conducted preclinical trials to test membranes produced from mesenchymal stem cells that can differentiate to cartilage and promote local immunoregulation.

A mutation in the variant’s spike protein is associated with glycosylation, which prevents antibodies from binding strongly to the virus. If the discovery is confirmed by further research, it could serve as a basis for future vaccines that are more effective against novel variants.

According to researchers affiliated with the University of São Paulo, these indicators can orient preventive care for the most vulnerable and rehabilitation for survivors who suffer from long-term complications.

In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.

Brazilian researchers show that feed supplementation improves fatty acid profile of milk and promotes a healthier omega-6/omega-3 ratio.

Researchers at the University of Campinas in Brazil reveal the mechanisms whereby SARS-CoV-2 disrupts the regulation of inflammation, coagulation and blood pressure when it infects alveolar cells, responsible for gas exchange in the lungs.

Researchers analyzed the effects of wildfires on plant cover and soil quality in the last 40 years. The findings of the study show that the forest is highly vulnerable even in well-conserved areas far from the ‘deforestation arc’.

Sample collection is much easier and less invasive. Self-collecting is feasible, depending on the child’s age. Schools should reopen only with mass testing to keep track of asymptomatic cases, the researchers argue.

People with diseases such as rheumatoid arthritis and lupus are more likely to have heart attacks, angina, and strokes. A review of the scientific literature on the subject shows that regular exercise improves vascular function in these patients.

A multinational research group used data from São Paulo to perform calculations which suggest that even a minor reduction in the city’s mobility – equivalent to a rise from 45% to 50% in the social distancing index – correlates with a considerable fall in new infections and deaths after a few days.

A simple and affordable solution developed by researchers at the University of São Paulo and a Nigerian collaborator eliminates even multi-resistant bacteria. Clay, papaya seeds and banana peel are among the raw materials used by the group.

Butterflies are considered a key biological indicator of trends in the biome. The study quantified the contributions of landscape and climate variables to current species distribution patterns.

Inexpensive test is non-invasive and based on detection of bladder cancer biomarkers in urine.

Infection of periodontal tissue, not just airways, explains the high viral load found in the saliva of COVID-19 patients, this study suggests.

An electrical impedance tomography system developed by a Brazilian company enabled critical care staff at a hospital run by Harvard University to adopt individualized mechanical ventilation strategies and reduced the need for extracorporeal membrane oxygenation (ECMO) therapy

A study by researchers at São Paulo State University reinforces the idea that environmental and climate-related changes resulting from the Andean uplift triggered a revolution in the caste system of these paper wasps.

Machines designed and prototyped by Setup Automação with PIPE-FAPESP’s support could come to market costing 25% less than currently available devices.

A clinical trial was conducted by researchers at the University of São Paulo with 240 patients who were given 200,000 IU of vitamin D3 on admission to hospital. The supplementation did not reduce length of stay or affect the proportion requiring intensive care.

Resonant-tunneling diodes are used in high-frequency oscillators, wave emitters and detectors, logic gates, photodetectors, and optoelectronic circuits. The study was a collaboration between Brazilian and German researchers.

A total of BRL 18.5 million will be allocated to funding for collaborative projects by researchers in the state of São Paulo with colleagues in other countries. Proposals must be submitted not later than July 10.

Researchers analyzed almost 30,000 RT-PCR tests on swabs from 4,269 players in 2020: 11.7% turned out positive. The rate was the same as among front-line health workers.

The researchers concluded that water stress, soil fertility and human-induced forest degradation cause gaps in the world’s largest tropical forest.

Researchers conducted the first large-scale survey of the microbiota present in the seamount’s ferromanganese crusts, describing bacteria and archaea involved in the nutrient cycle and formation of metals. Brazil has mineral exploration rights to the Rise, but mining there will have a major environmental impact.

A study led by researchers at the University of Campinas reinforces the need for prevention and follow-up treatment starting in early childhood to avoid development of this inflammatory disease of the gums.

The new cutoff values for a metric widely used by geriatricians, physical therapists and nutritionists are more accurate, facilitate early diagnosis and contribute to preventive treatment.

The law disciplines Brazil’s actions as a provider but not as a user of genetic resources from other countries, researcher Bráulio Dias noted during an online seminar held by FAPESP.

A study by the University of São Paulo has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.

Brazilian researchers monitoring the population of metropolitan São Paulo have reported atypical cases in which SARS-CoV-2 continues to replicate in the organism for longer than the recommended isolation period.

A method created in Brazil by the Human Genome and Stem Cell Research Center could be used for large-scale production of livers for transplantation.

The scientists detected incapacities related to gait timing and foot placement. Their discoveries serve as a basis for the development of an exercise protocol that mitigates the difficulty.

The platform developed by researchers from Brazil and Chile lets users view geolocation of cases, deaths and vaccinations over time.

By means of specific biomarkers, a diagnostic test developed by the Brazilian startup Onkos shows whether a lump in the gland is benign or malignant, reducing the risk of unnecessary surgery.

Brazilian researchers treated cells infected by SARS-CoV-2 with compounds produced by gut microbiota from dietary fiber. The intervention did not mitigate viral replication but reduced expression of a gene that plays a key role in viral entry into cells and a receptor involved in the inflammatory process.

In an online seminar hosted by FAPESP, researchers from Brazil, the United States and France analyzed the impact of the pandemic on educational inequality.

Extracorporeal membrane oxygenation (ECMO) can keep patients alive until the disease recedes.

Luciferin-luciferase system developed in collaboration with Japanese researchers produces brighter and longer-lasting far red light. The innovation can be used to image cells and tissues for diagnosis and biomedical research.

Researchers analyzed socioeconomic and environmental indicators for the 180 municipalities in the mega-region around São Paulo state capital, detecting environmental inequity and dependency.

Brazilians are working in more than 60 scientific fields in over 50 German cities. An online event hosted by the Brazilian Embassy in Berlin featured researchers and representatives of institutions.